Pre_GI: SWBIT SVG BLASTP

Query: NC_014618:690056 Enterobacter cloacae SCF1 chromosome, complete genome

Lineage: Enterobacter lignolyticus; Enterobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Country: USA; Environment: Soil; Temp: Mesophile; Isolation: Short Cloud Forest soil; Country:USA: Luquillo LTER, Puerto Rico. This organism was isolated anaerobically from tropical forest soils collected from the Short Cloud Forest site in the El Yunque National Forest in Puerto Rico, USA, part of the Luquillo Long-Term Ecological Research Station.

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BLASTP Alignment.txt

Subject: NC_008258:1934479 Shigella flexneri 5 str. 8401, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.