Query: NC_014614:2500301 Clostridium sticklandii, complete genome Lineage: Clostridium sticklandii; Clostridium; unclassified Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: This Clostridium (HF strain, ATCC 12662) was initially found associated with Methanococcus vannieli in formate-enriched cultures. After its isolation in pure culture, it was shown that this organism is capable of fermenting amino acids. Biochemical studies have shown that C. sticklandii obtains energy for growth from oxidation-reduction reactions between specific amino acid pairs. Clostridium sticklandii is a Gram-positive bacterium with low (G +C) content that is capable of fermenting amino acids.
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General Information: Nitrogen fixation. Thermophilic strictly anaerobic bacterium oxidizing acetate to CO2 in syntrophic association with a methanogenic partner. Capable of growing with various substrates such as alcohols and methylated nitrogen compounds, and to reduce sulfate in the presence of acetate. Isolated from sludge of an anaerobic digester run at 58 degrees C. Thermacetogenium phaeum is a strictly anaerobic, homoacetogenic bacterium. It is exceptional because it can use the homoacetogenic Wood-Ljungdahl (CO- dehydrogenase) pathway both for acetate formation and acetate oxidation. Acetate oxidation is possible only in syntrophic cooperation with a methanogenic partner which maintains a low hydrogen and/or formate concentration in the coculture. With this, the bacterium operates close to the thermodynamic equilibrium of substrate conversion, similar to other syntrophically fermenting bacteria such as Syntrophomonas wolfei the genomes of which have been sequenced as well in the recent past.