Query: NC_014387:2869914 Butyrivibrio proteoclasticus B316 chromosome 1, complete genome
Lineage: Butyrivibrio proteoclasticus; Butyrivibrio; Lachnospiraceae; Clostridiales; Firmicutes; Bacteria
General Information: Butyrivibrio proteoclasticus, formerly Clostridium proteoclasticum, was isolated from rumen contents of a cow. This organism is highly proteolytic and therefore probably involved in the degradation of proteins in the rumen.
Subject: NC_003103:164972 Rickettsia conorii str. Malish 7, complete genome
Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.