Query: NC_014363:480049 Olsenella uli DSM 7084 chromosome, complete genome Lineage: Olsenella uli; Olsenella; Coriobacteriaceae; Coriobacteriales; Actinobacteria; Bacteria General Information: Isolation: Human gingival crevice; Temp: Mesophile; Temp: 37C. The bacteria are nonmotile, Gram-positive rods that occur singly, in pairs, and in short chains; the central part of the cell may swell particularly when grown on solid medium. This strain is microaerotolerant to anaerobic and grows optimally at 37 degrees Celsius. Olsenella uli (formerly Lactobacillus uli) has been isolated from human gingival crevices and periodontal pockets.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.