Query: NC_014221:266638 Truepera radiovictrix DSM 17093 chromosome, complete genome
Lineage: Truepera radiovictrix; Truepera; Trueperaceae; Deinococcales; Deinococcus-Thermus; Bacteria
General Information: Isolation: Water sample from a hot spring runoffs; Country: Portugal; Temp: Thermophile; Temp: 50C; Habitat: Fresh water, Hot spring. Truepera radiovictrix is a radiation-resistant species was isolated from hot spring runoff on the Island of Sao Miguel in the Azores. The hot springs in this area discharge neutral to slightly alkaline water that may reach the boiling point. These strains form orange/red colonies, spherical-shaped cells, have an optimum growth temperature of about 50 degrees C, an optimum pH for growth between about 7.5 and 9.5, and do not grow at pH below 6.5 or above pH 11.2.
Subject: NC_010161:2050816 Bartonella tribocorum CIP 105476, complete genome
Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.