Query: NC_014212:3206860 Meiothermus silvanus DSM 9946 chromosome, complete genome Lineage: Meiothermus silvanus; Meiothermus; Thermaceae; Thermales; Deinococcus-Thermus; Bacteria General Information: Isolation: Hot spring; Country: Portugal; Temp: Thermophile; Temp: 50C; Habitat: Hot spring. An aerobic, thermophilic, nonmotile Gram-negative bacterium isolated from the hot spring located at the end of a 450 m tunnel and from thermal water piped to a spa at Vizela in northern Portugal. M. silvanus is of special interest as it causes colored biofilms in the paper making industry and may thus be of economic importance as a biofouler. M. silvanus has also been detected in the gut of an invasive wood-boring beetle and in seawater adjacent to a Pacillopora meandrina coral colony at Palmyra Atoll.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.