Query: NC_014165:2888961 Thermobispora bispora DSM 43833 chromosome, complete genome Lineage: Thermobispora bispora; Thermobispora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Isolation: Decaying manure; Temp: Thermophile; Temp: 55 - 65C; Isolation: decaying manure. Thermobispora bispora is a thermophilic actinomycete which is able to grow at 65 degrees C and not at 35 degrees C. This organism forms aerial mycelia which contain longitudinal pairs of spores.
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General Information: Causes bovine brucellosis. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism was first noticed on the island of Malta by Dr. David Bruce during an epidemic among British soldiers. It is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics.