Query: NC_014165:2888961 Thermobispora bispora DSM 43833 chromosome, complete genome Lineage: Thermobispora bispora; Thermobispora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Isolation: Decaying manure; Temp: Thermophile; Temp: 55 - 65C; Isolation: decaying manure. Thermobispora bispora is a thermophilic actinomycete which is able to grow at 65 degrees C and not at 35 degrees C. This organism forms aerial mycelia which contain longitudinal pairs of spores.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.