Query: NC_014160:43486 Thermosphaera aggregans DSM 11486 chromosome, complete genome Lineage: Thermosphaera aggregans; Thermosphaera; Desulfurococcaceae; Desulfurococcales; Crenarchaeota; Archaea General Information: Isolation: Hot spring from Obsidian Pool located in the Mud Volcano area of the Yellowstone National Park; Country: USA; Temp: Hyperthermophile; Temp: 85C; Habitat: Hot spring, Solfataric field. Thermosphaera aggregans is a hyperthermophilic archaeum isolated from terrestrial hot solfataric springs.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.