Query: NC_014121:489500 Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete Lineage: Enterobacter cloacae; Enterobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Enterobacter species are found in natural environments such as water, sewage, soil, and vegetables; some species are found in human and animal species. Enterobacter cloacae is a prevalent nosocomial pathogen as it is highly resistant to disinfectants and antimicrobial agents. E.cloacae subsp. cloacae strain ATCC 13047 was isolated from human cerebrospinal fluid in 1890 and is the type strain. These "ICU bugs" cause significant morbidity and mortality, and infection management is complicated by multiple antibiotic resistance. These bacteria possess inducible beta-lactamases, which are undetectable in vitro but are also responsible for resistance during treatment.
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General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.