Query: NC_014029:792719 Yersinia pestis Z176003 chromosome, complete genome Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: It was isolated from a dead marmot in Tibet Autonomous Region, China. Gram-negative straight rods, sometimes approaching a spherical shape. Y.pestis is always nonmotile. It is the causative agent of plague which is primarily a disease of wild rodents. Y.pestis is transmitted among wild rodents by fleas, in which the bacteria multiply and block the esophagus and the pharynx. The fleas regurgitate the bacteria when they take their next blood meal. Bacteria are transmitted subcutaneously to humans by the bite of infected fleas, but also by air, especially during pandemics of disease. Infective flea bites produce the typical bubonic form of plague in humans.
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General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.