Query: NC_013949:1163456 Helicobacter mustelae 12198 chromosome, complete genome Lineage: Helicobacter mustelae; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria General Information: Helicobacter mustelae was isolated from the gastric mucosa of a ferret. It is the natural colonizer of ferret gastric mucosa where it is found in association with a diffuse antral chronic gastritis and gastric ulcers. Inoculation of this bacteria into uninfected ferrets results in an inflammatory response similar to that seen in naturally infected animals, however, an association between gastric ulcers and Helicobacter mustelae infection has not yet been documented. All strains of this species have been reported to be urease, catalase and oxidase positive. Helicobacter mustelae is sensitive to 1.5% NaCl, metronidazole, and nalidixic acid and resistant to cephalothin and 5-fluorouracil.
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General Information: Isolated from a beaver that died of tularemia in Oklahoma in 1978. Causative agent of tularemia. This organism was first identified by Edward Francis as the causative agent of a plague-like illness that affected squirrels in Tulare county in California in the early part of the 20th century. The organism now bears his name. The disease, which has been noted throughout recorded history, can be transmitted to humans by infected ticks or deerflies, infected meat, or by aerosol, and thus is a potential bioterrorism agent. This organism has a high infectivity rate, and can invade phagocytic and nonphagocytic cells, multiplying rapidly. Once within a macrophage, the organism can escape the phagosome and live in the cytosol. It is an aquatic organism, and can be found living inside protozoans, similar to what is observed with Legionella.