Pre_GI: SWBIT SVG BLASTP

Query: NC_013929:3299736 Streptomyces scabiei 87.22 chromosome, complete genome

Lineage: Streptomyces scabiei; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This organism is a soil bacterium which is the causative agent of scab disease and affects a variety of underground vegetables such as potato and radish. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin.

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Subject: NC_008611:3579500 Mycobacterium ulcerans Agy99, complete genome

Lineage: Mycobacterium ulcerans; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This organism causes Buruli ulcer and is the third most common mycobacterial pathogen after Mycobacterium tuberculosis and Mycobacterium leprae. The disease has increased dramatically through central and West Africa since the late 1980s. Causative agent of Buruli and Bairnsdale ulcer. Infection by Mycobacterium ulcerans causes the formation of skin ulcers which, if left untreated, can lead to extensive scarring and/or amputation. Mycobacterium ulcerans produces a cytotoxin, mycolactone, which causes the destruction of skin tissue seen in this disease. This organism is resistant to antibiotics and treatment involves the surgical removal of infected tissues.