Query: NC_013928:370893 Streptococcus mutans NN2025, complete genome Lineage: Streptococcus mutans; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria General Information: This strain is a clinical serotype c strain isolated in Japan in 2002. Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Members of this genus vary widely in pathogenic potential. Most streptococci are facultative anaerobes, and some are obligate anaerobes. Streptococcus mutans was first isolated in 1924 from human carious (cavities) lesions and is the main cause of tooth decay. This organism thrives in a bacterial community known as a dental plaque which forms on the surface of teeth. This organism has also been implicated in cases of infective endocarditis.
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General Information: This biovar nodulates legumes in the Tribe Viciae (Vicia, Pisum, Lathyrus, Lens). This strain is a spontaneous streptomycin-resistant mutant of strain 300. Nitrogen-fixing plant symbiont. This organism, like other Rhizobia, establishes a symbiotic relationship with a legume plant, providing nitrogen in exchange for a protected environment. The legume roots secrete flavonoids and isoflavonoids which the bacteria recognize and use to turn on genes involved in root nodulation. Many of the root nodulation genes are involved in synthesis and secretion of a nodule inducing signal, a lipochito-oligosaccharide molecule, which the plant recognizes, triggering nodule formation. The bacterium is endocytosed and exists inside a membrane bound organelle, the symbiosome, and fixes nitrogen for the plant cell while the host cell provides carbon compounds for the bacterium to grow on. The nitrogen fixation is important as it obviates the need for expensive and environmentally damaging fertilizer use.