Query: NC_013798:345339 Streptococcus gallolyticus UCN34, complete genome Lineage: Streptococcus gallolyticus; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria General Information: Isolated from a human case of endocarditis associated with colon cancer in Caen, France in 2001. Streptococci are non-motile, Gram-positive cocci with widely varying pathogenic potential that occur in pairs or chains. Streptococcus gallolyticus (strain UCN34, biotype I) is a commensal Gram-positive bacterium isolated from various habitats, including feces of many animals and from human clinical sources. S. gallolyticus is part of the rumen flora but also a cause of disease in ruminants as well as in birds (septicemia in pigeons, outbreaks in broiler flocks, or bovine mastitis). This is a tannin-degrading Streptococcus species. Strains have been isolated from various habitats, including feces of many animals and from human clinical sources. This organism can be a cause of infectious endocarditis.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.