Query: NC_013791:1033700 Bacillus pseudofirmus OF4 chromosome, complete genome Lineage: Bacillus pseudofirmus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: This strain was isolated from soil in New York State by alkaline enrichment cultures. Because of its pH range and genetic accessibility, this alkaliphile has been extensively used as the model organism for studies of the bioenergetics of life at extremely high pH. This organism is a facultative, extreme alkaliphile that grows non-fermentatively as well as fermentatively in a pH range from near neutral to above pH 11.2.
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General Information: This strain (originally ZK, now E33L; Ethosha National Park, Namibia; isolate number 33; Large colony) was isolated from a swab of a dead zebra carcass in April, 1996. Soil microorganism that can cause food poisoning. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.