Query: NC_013716:4728500 Citrobacter rodentium ICC168, complete genome Lineage: Citrobacter rodentium; Citrobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.
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General Information: Isolated from Gilroy Hot Spring. The green sulfur bacteria (GSB; Phylum Chlorobi ) are commonly found in illuminated, stratified, and anoxic aquatic environments, sediments, and other sulfide-rich environments including hot springs. This bacterium has been used to model a variety of enzyme and reaction center pathways, including ATP-citrate lyase, isocitrate dehydrogenase, and the reverse Krebs cycle used in photosynthesis. Now called the "reductive carbolic acid cycle", this was found to be the sole carbon dioxide assimilation pathway in other green sulfur bacteria since its discovery.