Query: NC_013716:2255102 Citrobacter rodentium ICC168, complete genome Lineage: Citrobacter rodentium; Citrobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.
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General Information: This bacterium was isolated from a seawater sediment sample in the North Sea. The species is able to use Mihagol-S (C14,15-n-alkanes) as a principal carbon source. Using n-alkanes as a sole carbon source causes the strains to produce extracellular and membrane-bound surface-active glucose lipids. Phenotypic analysis showed a restricted nutritional profile, high halotolerance, the absence of fermentative metabolism, and a low G+C content. This, in combination with a 16S phylogenetic study, allowed the placing of this organism into a new genus.