Pre_GI: SWBIT SVG BLASTP

Query: NC_013508:1491945 Edwardsiella tarda EIB202, complete genome

Lineage: Edwardsiella tarda; Edwardsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Edwardsiella tarda is a Gram-negative member of the normal gut microflora of fish, humans, chickens and other animals. This organism is also a serious pathogen of marine and freshwater fish and has been isolated from channel catfish, Japanese eels, flounder, tilapia, and other economically important fish. Infection by this organism is characterized by septicemia, internal abscesses, and skin lesions. This disease is often associated with poor water quality and mortality in aquaculture can be high. Edwardsiella tarda also causes opportunistic infections in humans, most commonly gastroenteritis and wound infections. However, this organism has been isolated from cases of septicemia and meningitis, primarily in immunocompromised patients.

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BLASTP Alignment.txt

Subject: NC_004741:2009769 Shigella flexneri 2a str. 2457T, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.