Query: NC_013316:371953 Clostridium difficile R20291, complete genome Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
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General Information: This organism was isolated from the sea floor of a solfataric (volcanic area that gives off gas) environment with temperatures up to 112 degrees C at a depth of 9 m, off the shore of Sao Miguel Island, Azores. Hyperthermophilic sulfur-reducing archaeon. This bacterium is an extreme hyperthermophilic, anaerobic, sulfur-reducing archaeon. Grows optimally at 95-106 degress C, with a NaCl concentration of 17 g/l and a pH of 7.0.