Query: NC_013316:1 Clostridium difficile R20291, complete genome Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
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General Information: Environment: Deep sea, Fresh water, Hydrothermal vent; Isolation: Walls of an active deep-sea hydrothermal; Temp: Thermophile; Temp: 60 - 80C; Country: Pacific Ocean. This is a thermophilic, anaerobic, chemolithoautotrophic bacterium isolated from the walls of an active deep-sea hydrothermal vent chimney on the East Pacific Rise. This organism grows on mineral salts in the presence of carbon dioxide and hydrogen, reducing nitrate or sulfur to ammonium or hydrogen sulfide, respectively.