Query: NC_013192:1886337 Leptotrichia buccalis DSM 1135, complete genome Lineage: Leptotrichia buccalis; Leptotrichia; Leptotrichiaceae; Fusobacteriales; Fusobacteria; Bacteria General Information: Temp: Mesophile; Temp: 37C; Habitat: Blood, Human oral microflora. Leptotrichia buccalis DSM 1135 was isolated from dental plaque. This organism is a member of the normal human oral microbial community but has occasionally been implicated in cases of septicemia and endocarditis.
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General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.