Query: NC_013159:3858425 Saccharomonospora viridis DSM 43017, complete genome Lineage: Saccharomonospora viridis; Saccharomonospora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This organism has been implicated in a range of hypersensitivity pneumonitides, including farmer's lung disease. Symptoms of the disease develop in susceptible individuals following the inhalation of spores from overheated materials such as moldy hay and bagasse, or from forced-air heating and humidification systems. Prolonged exposure to the antigens results in acute respiratory distress which may lead to irreversible lung damage. Saccharomonospora viridis DSM 43017 was isolated from Irish peat and was originally classified as Thermomonospora viridis.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.