Query: NC_013009:689978 Neorickettsia risticii str. Illinois, complete genome Lineage: Neorickettsia risticii; Neorickettsia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria General Information: Neorickettsia risticii str. Illinois was isolated from horse blood in Maryland, USA. Neorickettsia risticii, formerly Ehrlichia risticii, is an obligate intracellular bacterium related to the Rickettsia. It can be transmitted from flukes that infest snails, fish or aquatic insects to horses by ingestion. This organism causes Potomac horse fever, also knows as equine monocytic ehrlichiosis, an acute diarrheal disease.
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General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.