Query: NC_012987:32296 Methylobacterium extorquens DM4 plasmid p1METDI, complete sequence Lineage: Methylobacterium extorquens; Methylobacterium; Methylobacteriaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Methylobacterium extorquens DM4 was isolated from soil contaminated with halogenated (chlorine-containing) hydrocarbons. This organism is able to use dichloromethane as a sole carbon and energy source. Dichloromethane, an industrial solvent, is toxic and carcinogenic. This compound is water soluble and can easily contaminate groundwater. Methylobacterium chloromethanicum was isolated from soil at a petrochemical factory in Tatarstan, Russia. This organism is able to grow using chloromethane as the sole carbon and energy source.
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General Information: This organism was discovered in 1819 by Bizio who named the organism after the Italian physicist Serrati. It was considered a nonpathogenic organism until late in the 20th century, although pathogenicity was noted as early as 1913. Serratia marcescens is an opportunistic human pathogen that is increasingly associated with life-threatening hospital-acquired infections. It is an environmental organism that has a broad host range, and is capable of infecting vertebrates and invertebrates, as well as plants. In humans, Serratia marcescens can cause meningitis (inflammation of the membrane surrounding the brain and spinal cord), endocarditis (inflammation of heart muscle) and pyelonephritis (inflammation of the kidneys). Many strains are resistant to multiple antibiotics. Environmental isolates are noted by production of the red pigment prodigiosin.