Query: NC_012962:4942000 Photorhabdus asymbiotica, complete genome Lineage: Photorhabdus asymbiotica; Photorhabdus; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: This strain is a North American clinical isolate from human blood. Photorhabdus asymbiota, formerly Xenorhabdus luminescens, has been isolated from human wound and blood infections often in association with spider bites. This species can also be isolated from the entomopathogenic nematode Heterorhabditis indica. Photorhabdus asymbiota is divided into two subspecies, subsp. australis which contains the Australian clinical isolates and subsp. asymbiota which contains the North American isolates. Photorhabdus is currently subdivided into three species, luminescens, temperate and asymbiotica all of which have been isolated as symbionts of heterorhabditid nematodes. This organism is unusual in that it is symbiotic within one insect, and pathogenic in another, the only organism that is known to exhibit this dual phenotype.
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General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.