Query: NC_012881:3362955 Desulfovibrio salexigens DSM 2638, complete genome Lineage: Desulfovibrio salexigens; Desulfovibrio; Desulfovibrionaceae; Desulfovibrionales; Proteobacteria; Bacteria General Information: Isolation: mud in British Guyana; Temp: Mesophile; Temp: 37 C; Habitat: Mud. Desulfovibrio are sulfate-reducing bacteria which reduce sulfate to sulfide found in soil, freshwater, saltwater and the intestinal tract of animals. These organisms typically grow anaerobically, although some can tolerate oxygen, and they utilize a wide variety of electron acceptors, including sulfate, sulfur, nitrate, and nitrite, as well as others. A number of toxic metals are reduced, including uranium (VI), chromium (VI) and iron (III), making these organisms of interest as bioremediators. These organisms are responsible for the production of poisonous hydrogen sulfide gas in marine sediments and in terrestrial environments such as drilling sites for petroleum products.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.