Query: NC_012846:1741000 Bartonella grahamii as4aup, complete genome Lineage: Bartonella grahamii; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Bartonella grahamii (strain as4aup) is Gram-negative bacterium isolated from a wood mouse (Apodemus sylvaticus) in central Sweden. Bartonella are human and animal pathogens which infect erythrocytes and can cause angiogenic lesions. These organisms cause diseases in humans such as Oroya fever, Trench fever, endocarditis, and Cat Scratch disease. Transmission of this organism is via the bite of a blood-sucking arthropod. Bartonella grahamii can be isolated from the blood of rodents and is found world wide. Fleas may be the transmission vector for Bartonella grahamii to other rodents. Human disease appears to be rare and associated with an immunocompromised state.
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General Information: This organism was one of the first bacteria studied, and was named Vibrio subtilis in 1835 and renamed Bacillus subtilis in 1872. It is one of the most well characterized bacterial organisms, and is a model system for cell differentiation and development. This soil bacterium can divide asymmetrically, producing an endospore that is resistant to environmental factors such as heat, acid, and salt, and which can persist in the environment for long periods of time. The endospore is formed at times of nutritional stress, allowing the organism to persist in the environment until conditions become favorable. Prior to the decision to produce the spore the bacterium might become motile, through the production of flagella, and also take up DNA from the environment through the competence system. The sporulation process is complex and involves the coordinated regulation of hundreds of genes in the genome. This initial step results in the coordinated asymmetric cellular division and endospore formation through multiple stages that produces a single spore from the mother cell.