Query: NC_012803:1839809 Micrococcus luteus NCTC 2665, complete genome Lineage: Micrococcus luteus; Micrococcus; Micrococcaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Temp: Mesophile; Habitat: Soil. Micrococcus luteus NCTC 2665 has potential in bioremediation due to its ability to sequester metals (i.e. gold and strontium), and it is being used for gold concentration from low-abundance ores. Micrococcus luteus was originally isolated by Alexander Fleming in 1929 as Micrococcus lysodeikticus. This organism can be found in many environments including soil, water, animals, and dairy products. Micrococcus luteus is able to survive in the environment for long periods and has been isolated from inclusions in amber.
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General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.