Query: NC_012781:302387 Eubacterium rectale ATCC 33656, complete genome Lineage: Eubacterium rectale; Eubacterium; Eubacteriaceae; Clostridiales; Firmicutes; Bacteria General Information: Eubacterium rectale ATCC 33656 was isolated from human feces. This genus has been isolated as normal flora from feces, rumen, and periodontal tissue. Eubacterium spp. are thought to play a beneficial role in maintaining the normal ecology of the large intestine, in part by producing chemicals like butyric acid which act to inhibit the growth of other bacteria. These organisms are occasionally isolated from wounds and abscesses and may be an opportunistic pathogen. This genus has also been isolated from sewage and soil.
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General Information: This is a serogroup A strain isolated in Gambia in 1983. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.