Query: NC_012730:652092 Rickettsia peacockii str. Rustic, complete genome Lineage: Rickettsia peacockii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: Rickettsia peacockii was initially identified in wood ticks from the eastern side of the Bitterroot Valley in Montana. Cases of Rocky Mountain spotted fever in the Bitterroot Valley are associated with exposure to ticks from the western side. Ticks from the east side are primarily infected with R. peacockii which is nonvirulent and may prevent the establishment of pathogenic Rickettsia species in these ticks.
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General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.