Pre_GI: SWBIT SVG BLASTP

Query: NC_012658:3778822 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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BLASTP Alignment.txt

Subject: NC_016024:1764516 Candidatus Chloracidobacterium thermophilum B chromosome chromosome

Lineage: Chloracidobacterium thermophilum; Chloracidobacterium; Acidobacteriaceae; ; Acidobacteria; Bacteria

General Information: This organism produces bacteriochlorophyll a and c under oxic conditions and represents a new group of photosynthetic bacteria. The only known chlorophototroph in the phylum Acidobacteria. Aerobic photoheterotroph that lacks the ability to synthesize several essential nutrients. Naturally inhabits microbial mats of alkaline siliceous hot springs in Yellowstone National Park.