Pre_GI: SWBIT SVG BLASTP

Query: NC_012563:4101000 Clostridium botulinum A2 str. Kyoto, complete genome

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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BLASTP Alignment.txt

Subject: NC_007514:335085 Chlorobium chlorochromatii CaD3, complete genome

Lineage: Chlorobium chlorochromatii; Chlorobium; Chlorobiaceae; Chlorobiales; Chlorobi; Bacteria

General Information: Chlorobium chlorochromatii CaD3 was isolated from a phototrophic consortia obtained from a freshwater lake in Germany. Chlorobium chlorochromatii is an green sulfur bacterium isolated from low temperature anaerobic fresh water habitats. This organism grows as part of a phototrophic consortium which consists of a colorless central bacterium surrounded by chlorosome-containing green sulfur epibionts. This organism is able to be grown in pure culture therefore is not an obligate symbiont. This organism is an obligate anaerobic phototroph able to fix nitrogen.