Query: NC_012483:30784 Acidobacterium capsulatum ATCC 51196, complete genome Lineage: Acidobacterium capsulatum; Acidobacterium; Acidobacteriaceae; Acidobacteriales; Acidobacteria; Bacteria General Information: Isolated from acidic mine drainage in Yanahara mine, Okayama, Japan. Acidophilic bacterium. This genus comprises a number of species commonly found in water reservoirs, microbial mats, many different soil types, marine and freshwater sediments, as well as in hot-spring mats and sediments, etc. Furthermore, they sometimes form the dominant group in a habitat. These bacteria are involved in the first step of destruction of biologically complex molecules produced by autotrophic (capable of synthesizing their own nutrients) microorganisms. Acidobacterium capsulatum is an aerobic, mesophilic, chemo-organotroph able to use a variety of carbon sources and to grow up to pH 6.0. The species comprises several strains characterized by orange pigmentation, production of menoquinones as their sole quinones, and branched-chain iso fatty acids as their cell envelope components.
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General Information: This strain is a standard laboratory strain. It is virulent for humans and cattle. Causes bovine brucellosis. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism was first noticed on the island of Malta. It is the primary cause of bovine brucellosis, which results in enormous (billions of dollars) economic losses due primarily to reproductive failure and food losses. In man, it causes undulant fever, a long debilitating disease that is treated by protracted administration of antibiotics.