Query: NC_012483:3000619 Acidobacterium capsulatum ATCC 51196, complete genome Lineage: Acidobacterium capsulatum; Acidobacterium; Acidobacteriaceae; Acidobacteriales; Acidobacteria; Bacteria General Information: Isolated from acidic mine drainage in Yanahara mine, Okayama, Japan. Acidophilic bacterium. This genus comprises a number of species commonly found in water reservoirs, microbial mats, many different soil types, marine and freshwater sediments, as well as in hot-spring mats and sediments, etc. Furthermore, they sometimes form the dominant group in a habitat. These bacteria are involved in the first step of destruction of biologically complex molecules produced by autotrophic (capable of synthesizing their own nutrients) microorganisms. Acidobacterium capsulatum is an aerobic, mesophilic, chemo-organotroph able to use a variety of carbon sources and to grow up to pH 6.0. The species comprises several strains characterized by orange pigmentation, production of menoquinones as their sole quinones, and branched-chain iso fatty acids as their cell envelope components.
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General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.