Query: NC_012471:51305 Streptococcus equi subsp. equi 4047, complete genome Lineage: Streptococcus equi; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria General Information: Streptococcus equi equi is an obligate parasitic bacterium and is the causative agent of a serious upper respiratory tract disease within members of the family Equidae (horses), called strangles. Strangles is a highly contagious disease of the nasopharynx and lymph nodes. The genome sequence of this organism will provide information into the production and regulation of virulence factors involved in this disease. Pathogenic in horses, goats and sheep. Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Members of this genus vary widely in pathogenic potential. Most streptococci are facultative anaerobes, and some are obligate anaerobes.
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General Information: USA300, a methicillin resistant strain of Staphylococcus aureus, has been implicated in epidemiologically unassociated outbreaks of skin and soft tissue infections among healthy individuals in at least 21 U.S. states, Canada and Europe. USA300 is also noted for its strong association with unusually invasive disease, including severe septicemia, necrotizing pneumonia and necrotizing fasciitis. Staphylcocci are generally found inhabiting the skin and mucous membranes of mammals and birds. Some members of this genus can be found as human commensals and these are generally believed to have the greatest pathogenic potential in opportunistic infections. This organism is a major cause of nosocomial (hospital-acquired) and community-acquired infections. S. aureus continues to be a major cause of mortality and is responsible for a variety of infections including, boils, furuncles, styes, impetigo and other superficial skin infections in humans. Also known to cause more serious infections particularly in the chronically ill or immunocompromised. The ability to cause invasive disease is associated with persistance in the nasal cavity of a host.