Query: NC_012438:1514376 Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genome Lineage: Sulfurihydrogenibium azorense; Sulfurihydrogenibium; Hydrogenothermaceae; Aquificales; Aquificae; Bacteria General Information: This strain was isolated from a terrestrial hot spring in the Azores, where it was living at temperatures between 65 degrees C and 70 degrees C. Hydrogen-oxidizing thermophile. Sulfurihydrogenibium azorense is a thermophilic bacterium that is able to use hydrogen and sulfur compounds as electron donors. This organism is also able to use ferric iron and arsenate as electron acceptors. This is the first pure culture terrestrial member of the Aquificales group, isolated by dilution-to-extinction methods.
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General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.