Query: NC_011916:467106 Caulobacter crescentus NA1000 chromosome, complete genome Lineage: Caulobacter vibrioides; Caulobacter; Caulobacteraceae; Caulobacterales; Proteobacteria; Bacteria General Information: Caulobacter crescentus NA1000 is a spontaneous mutant derivative of C. crescentus strain CB15. It is used by labs worldwide because it can easily be synchronized, allowing for studies of the bacterial cell cycle. Caulobacter vibroides, also known as Caulobacter crescentus, inhabits aquatic environments and plays an important part in biogeochemical cycling of organic nutrients. This bacterium undergoes an unusual developmental cycle in which a swarming motile cell becomes a stalked cell that is attached to a solid surface. The stalked cell then undergoes asymmetric cell division and produces one flagellated motile daughter cell and one stalked daughter cell. Thus, the asymmetric processes in this organism provide useful models for differentiation and development. This organism also contains a number of energy-dependent transport system, presumably enabling growth in the substrate-sparse aquatic environments that it lives in.
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General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.