Pre_GI: SWBIT SVG BLASTP

Query: NC_011601:756885 Escherichia coli O127:H6 str. E2348/69 chromosome, complete genome

Lineage: Escherichia coli; Escherichia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Enteropathogenic Escherichia coli (EPEC) is an important cause of fatal infant diarrhea. EPEC induces diarrhea by attaching and effacing to host cells in the small intestine, inducing cytoskeletal rearrangements that result in pedastel formation, and then by introducing toxins into the host cell. This organism was named for its discoverer, Theodore Escherich, and is one of the premier model organisms used in the study of bacterial genetics, physiology, and biochemistry. This enteric organism is typically present in the lower intestine of humans, where it is the dominant facultative anaerobe present, but it is only one minor constituent of the complete intestinal microflora. E. coli, is capable of causing various diseases in its host, especially when they acquire virulence traits. E. coli can cause urinary tract infections, neonatal meningitis, and many different intestinal diseases, usually by attaching to the host cell and introducing toxins that disrupt normal cellular processes.

Subject: NC_008309:1827809 Haemophilus somnus 129PT, complete genome

Lineage: Histophilus somni; Histophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: This strain is an asymptomatic carrier strain that was serum-resistant. Causes disease in cattle. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism is a major cause of disease in feedlot cattle. It causes constriction of blood vessels supplying major organs, restricting blood supply which leads to reduced oxygen delivery, and leads to tissue damage and death. The diseases that result are pneumonia, arthritis, myocarditis (inflammation of heart muscle), and reproductive problems resulting in the loss of millions of dollars in animals each year.