Query: NC_011565:190406 Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2, Lineage: Azobacteroides pseudotrichonymphae; Azobacteroides; ; Bacteroidales; Bacteroidetes; Bacteria General Information: Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 was isolated from a single cell of the protist Pseudotrichonympha grassii which resides in the termite gut. Gram-negative bacteria that are specifically found within the cytoplasm of the parabasalid protist Pseudotrichonympha grassii which resides in the hindgut of the termite Coptotermes formosanus. Candidatus Azobacteroides pseudotrichonymphae may be involved in providing nitrogen compounds for the host.
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General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.