Query: NC_010994:57362 Rhizobium etli CIAT 652, complete genome Lineage: Rhizobium etli; Rhizobium; Rhizobiaceae; Rhizobiales; Proteobacteria; Bacteria General Information: It is a nitrogen-fixing symbiotic bacteria that interacts with the root of the common bean plant Phaseolus vulgaris. The molecular biology and evolution of R. etli and its relation to other nitrogen/fixing symbionts has been well studied. The genomic sequence will provide information on the process of symbiosis, on the genetic systems that allow the survival and adaptations of this bacteria to the soil, and on the evolutionary relationship and the symbiosis origin of this organism.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.