Query: NC_010741:745357 Treponema pallidum subsp. pallidum SS14, complete genome Lineage: Treponema pallidum; Treponema; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria General Information: Treponema pallidum subsp. pallidum SS14 was isolated in 1977 from a patient with secondary syphilis. This strain is less susceptible than the Nichols strain for a number of antibiotics. This organisms is divided into subspecies each of which causes a specific disease. This organism is the causative agent of endemic and venereal syphilis. This sexual transmitted disease was first discovered in Europe at the end of the fifteenth century, however, the causative agent was not identified until 1905. At one time syphilis was the third most commonly reported communicable disease in the USA. Syphilis is characterized by multiple clinical stages and long periods of latent, asymptomatic infection. Although effective therapies have been available since the introduction of penicillin, syphilis remains a global health problem.
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General Information: This strain is a human clinical isolate from a human burn patient. It is infectious in mice, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. Opportunistic pathogen. Bacteria belonging to the Pseudomonas group are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. Pseudomonas bacteria are found in nature in a biofilm or in planktonic form. Pseudomonas bacteria are renowned for their metabolic versatility as they can grow under a variety of growth conditions and do not need any organic growth factors. This organism is an opportunistic human pathogen. While it rarely infects healthy individuals, immunocompromised patients, like burn victims, AIDS-, cancer- or cystic fibrosis-patients are at increased risk for infection with this environmentally versatile bacteria. It is an important soil bacterium with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controlled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. The bacterium is naturally resistant to many antibiotics and disinfectants, which makes it a difficult pathogen to treat.