Query: NC_010725:750911 Methylobacterium populi BJ001, complete genome Lineage: Methylobacterium populi; Methylobacterium; Methylobacteriaceae; Rhizobiales; Proteobacteria; Bacteria General Information: This species was isolated from tissue cultures of Populus, the Poplar tree. Colonies are pink to red, and the red pigment is water insoluble. Species of the genus Methylobacterium are strictly aerobic, facultatively methylotrophic, Gram-negative, rod-shaped bacteria that are able to grow on one-carbon compounds (e.g. methanol or methylamine), as well as on a variety of C2, C3 and C4 substrates. Only the type species, Methylobacterium organophilum, has been shown to use methane as the sole source of carbon and energy. Members of the genus are distributed in a wide variety of natural and man-made environments, including soil, air, dust, fresh- and marine water and sediments, water supplies, bathrooms, air-conditioning systems and masonry, and some are opportunistic human pathogens.
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General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.