Query: NC_010682:701912 Ralstonia pickettii 12J chromosome 1, complete sequence Lineage: Ralstonia pickettii; Ralstonia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: Ralstonia pickettii 12J was isolated from copper-contaminated sediment from a lake in Michigan, USA. In addition to being highly resistant to copper, strain 12J is also resistant to zinc and cadmium. Ralstonia pickettii can be isolated from a wide range of environmental and clinical samples. This species is a nocosomial pathogen. It is associated with infections caused by contaminated solutions, such as distilled water and intravenous solutions. Ralstonia pickettii strains resistant to heavy metals have also been isolated from heavy metal contaminated environments.
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General Information: This strain was originally isolated from a patient with whooping cough and has been studied extensively for over 40 years. Causative agent of whooping cough. This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. This organism, which is unable to persist in the environment, is a strict human pathogen that causes whooping cough. Once a common cause of death in children the development of a vaccine has greatly decreased the number of deaths due to Bordetella pertussis. However, this organism infects and estimated 39 million people and kills hundreds of thousands of people each year.