Pre_GI: SWBIT SVG BLASTP

Query: NC_010673:479552 Borrelia hermsii DAH, complete genome

Lineage: Borrelia hermsii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: This strain was isolated from a case of relapsing fever in western Washington, USA. Borrelia hermsii is the causative agent of tick-borne relapsing fever in the western United States and Canada. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another. These plasmids carry genes involved in antigenic variation and pathogenicity.

Subject: NC_006831:250074 Ehrlichia ruminantium str. Gardel, complete genome

Lineage: Ehrlichia ruminantium; Ehrlichia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from the Caribbean island of Guadeloupe. Obligate intracellular bacterium and causative agent of heartwater. This organism causes heartwater, a disease with a high mortality rate that affects both wild and domesticated ruminants in sub-Saharan Africa and parts of the Caribbean. The name heartwater refers to the hydropericardium (excessive fluid in the sac surrounding the heart) commonly found associated with infection. This organism is found in membrane-bound vacuoles in endothelial cells and neutrophils and is an obligate intracellular parasite.