Query: NC_010644:1491357 Elusimicrobium minutum Pei191, complete genome Lineage: Elusimicrobium minutum; Elusimicrobium; Elusimicrobiaceae; Elusimicrobiales; Elusimicrobia; Bacteria General Information: Elusimicrobium minutum (strain Pei191) is a mesophilic, obligately anaerobic free-living ultramicrobacterium with a Gram-negative cell envelope isolated from the intestinal cluster from the hindgut of a humivorous scarab beetle larva. This species is an endosymbiont of flagellated protists which occur almost exclusively in the hindgut of termites and wood-feeding cockroaches.
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General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.