Query: NC_010524:3445641 Leptothrix cholodnii SP-6, complete genome Lineage: Leptothrix cholodnii; Leptothrix; Comamonadaceae; Burkholderiales; Proteobacteria; Bacteria General Information: Leptothrix cholodnii SP-6 was isolated from water and flocculent from an artificial iron seep in Ithaca, NY, USA. Leptothrix cholodnii, like other Leptothrix species is an iron- and manganese-oxidizing, sheathed bacterium common in organic rich aquatic environments. Iron oxides and manganese oxides often coat the sheathes of these organisms.
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General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.