Pre_GI: SWBIT SVG BLASTP

Query: NC_010516:3759136 Clostridium botulinum B1 str. Okra, complete genome

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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BLASTP Alignment.txt

Subject: NC_012471:51305 Streptococcus equi subsp. equi 4047, complete genome

Lineage: Streptococcus equi; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: Streptococcus equi equi is an obligate parasitic bacterium and is the causative agent of a serious upper respiratory tract disease within members of the family Equidae (horses), called strangles. Strangles is a highly contagious disease of the nasopharynx and lymph nodes. The genome sequence of this organism will provide information into the production and regulation of virulence factors involved in this disease. Pathogenic in horses, goats and sheep. Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Members of this genus vary widely in pathogenic potential. Most streptococci are facultative anaerobes, and some are obligate anaerobes.