Query: NC_010424:214640 Candidatus Desulforudis audaxviator MP104C, complete genome
Lineage: Desulforudis audaxviator; Desulforudis; Peptococcaceae; Clostridiales; Firmicutes; Bacteria
General Information: Its genome indicates a motile, sporulating, sulfate-reducing, chemoautotrophic thermophile that can fix its own nitrogen and carbon by using machinery shared with archaea. Candidatus Desulforudis audaxviator is a gram positive sulfate reducing bacteria identified in fracture water from a borehole at a depth of 2.8 km in a South African gold mine. Water from these boreholes is very old (low-biodiversity fracture water), suggesting that these bacteria have been isolated from the Earth's surface for as much as several million years.
Subject: NC_013316:1 Clostridium difficile R20291, complete genome
Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria
General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.