Query: NC_010382:4479464 Lysinibacillus sphaericus C3-41, complete genome
Lineage: Lysinibacillus sphaericus; Lysinibacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria
General Information: Lysinibacillus sphaericus C3-41 was isolated from a mosquito breeding site in China. This organism is highly toxic to Culex species of mosquito. Lysinibacillus sphaericus, formerly Bacillus sphaericus, is a common environmental organism which produces an insecticidal toxin similar to that produced by Bacillus thuringiensis. Lysinibacillus sphaericus produces two proteins during sporulation which accumulate in parasporal crystalline inclusions. These proteins bind in the gastric cavitiy and midgut of the larvae causing disruption of feeding by the infected host and death.
Subject: NC_007793:574580 Staphylococcus aureus subsp. aureus USA300, complete genome
Lineage: Staphylococcus aureus; Staphylococcus; Staphylococcaceae; Bacillales; Firmicutes; Bacteria
General Information: USA300, a methicillin resistant strain of Staphylococcus aureus, has been implicated in epidemiologically unassociated outbreaks of skin and soft tissue infections among healthy individuals in at least 21 U.S. states, Canada and Europe. USA300 is also noted for its strong association with unusually invasive disease, including severe septicemia, necrotizing pneumonia and necrotizing fasciitis. Staphylcocci are generally found inhabiting the skin and mucous membranes of mammals and birds. Some members of this genus can be found as human commensals and these are generally believed to have the greatest pathogenic potential in opportunistic infections. This organism is a major cause of nosocomial (hospital-acquired) and community-acquired infections. S. aureus continues to be a major cause of mortality and is responsible for a variety of infections including, boils, furuncles, styes, impetigo and other superficial skin infections in humans. Also known to cause more serious infections particularly in the chronically ill or immunocompromised. The ability to cause invasive disease is associated with persistance in the nasal cavity of a host.